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Briumvi® (ublituximab-xiiy) is a monoclonal antibody therapy used to treat adults with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It belongs to a group of medications called anti-CD20 therapies, which are designed to target and reduce B cells — immune cells that play a major role in the body's attack on the nervous system in MS.
Briumvi is administered through intravenous (IV) infusion at our specialized infusion center. The typical infusion schedule includes:
This twice-yearly schedule provides an effective and convenient treatment option for individuals needing B-cell–depleting therapy.
The Briumvi® infusion cost can vary depending on several factors, such as your insurance plan and coverage. At MS & Neuromuscular Center of Excellence, our goal is to make treatment more accessible and less stressful for every patient.
We partner with nearly all major insurance providers throughout the region — including Aetna, BayCare, Advent Health, Cigna, AvMed, Assurant, and others. Our team works closely with your insurance company to ensure you receive the maximum coverage available for your Briumvi treatment.
Our dedicated infusion team provides comprehensive support to make treatment more accessible:
This removes the administrative burden from you so you can focus on your health.
In multiple sclerosis (MS), the immune system mistakenly attacks the myelin sheath — the protective layer surrounding nerve cells in the brain and spinal cord. When the myelin is damaged, nerve signals are disrupted, which can cause symptoms affecting coordination, balance, movement, speech, vision, and even bowel function.
One of the main immune cells involved in this damaging process is the B cell, which carries a marker known as CD20 on its surface. Briumvi works by:
What makes Briumvi unique among anti-CD20 therapies is its engineered structure, which allows for faster infusion times compared to some other B-cell depleting medications.
While Briumvi does not cure MS, it helps reduce inflammation and slow the disease's progression by preventing B cells from causing further attacks on the nervous system. Briumvi begins working in your body within 24 hours of the first infusion, but it typically takes several weeks to months to observe its full effect in reducing relapses and disease progression. Clinical studies demonstrating significant results evaluated patients over 96 weeks (nearly two years), with long-term data now available showing sustained benefits up to six years. Most patients can expect to see a reduction in relapse frequency and a slowing of disability progression as the medication takes full effect.
Like all medications, Briumvi can cause side effects, though not everyone experiences them. Common Briumvi infusion symptoms include:
Serious Briumvi side effects require immediate medical attention and include:
Your healthcare team will monitor you closely during and after each infusion to ensure your safety.
Our infusion center is led by board-certified neurologists and supported by BSN-prepared Registered Nurses who specialize in neurological and immunomodulatory infusion therapies. Our team has extensive experience caring for patients with multiple sclerosis (MS), particularly those receiving advanced B-cell–depleting treatments like Briumvi®.
Our comprehensive approach to MS infusion care includes:
Beyond Multiple Sclerosis, our multidisciplinary neurological team provides expertise across the full spectrum of neurologic conditions — including myasthenia gravis, neuropathy & vein disease, and more.
We manage prior authorizations and benefits verification while helping patients navigate copay and foundation assistance programs. Our goal is to reduce financial stress and make therapy as affordable as possible.
A Cigna study found that patients treated in physician-owned infusion centers — like MS & Neuromuscular Center of Excellence's Infusion Center — typically have much lower out-of-pocket and overall costs compared to those treated at hospital-based centers.
For 35+ years MS & Neuromuscular Center of Excellence has provided specialized care for individuals with multiple sclerosis and other neurological conditions across the region. Our years of experience treating thousands of patients with complex neurological disorders have refined our clinical expertise and deepened our understanding of the challenges our patients face.
This long-standing commitment to excellence means you benefit from a team that has witnessed the evolution of MS treatments, from early disease-modifying therapies to today's advanced infusion options like Briumvi. Our established reputation and track record of successful patient outcomes make us a trusted leader in neurological care throughout the region.
Referral Form:
Briumvi®What It Treats:
Multiple Sclerosis
FDA Approval:
Briumvi® (ublituximab-xiiy): Approved in December 2022
Manufacturer:
TG Therapeutics, Inc.
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
