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Ocrevus® (ocrelizumab) is a monoclonal antibody therapy designed to treat both relapsing forms of multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS) in adults. It's part of the anti-CD20 therapy class, which targets and removes specific B cells — immune cells known to contribute to the nerve damage associated with MS.
What sets Ocrevus apart from many other MS treatments is its ability to address both relapsing and progressive forms of the disease, making it one of the most comprehensive treatment options available. In fact, Ocrevus is the first FDA-approved therapy for primary progressive MS, offering hope to patients who previously had limited treatment options.
Ocrevus infusion is administered intravenously at our specialized infusion center. The initial treatment involves:
Premedications (corticosteroid and antihistamine) are given before each infusion to reduce the risk of reactions. Patients are monitored for at least one hour after each infusion. For those who tolerate the treatment well, a shorter infusion option may be available for maintenance doses.
In MS, the immune system attacks the myelin sheath — the insulating layer around nerves in the brain and spinal cord that allows efficient communication between nerve cells. Damage to this sheath can disrupt nerve signals, leading to symptoms such as muscle weakness, coordination difficulties, visual disturbances, and cognitive changes.
Ocrevus works by targeting a specific type of immune cell involved in this process:
What makes Ocrevus unique is its proven effectiveness in treating both relapsing and primary progressive forms of multiple sclerosis. For relapsing MS, it significantly reduces the frequency of relapses and slows disability progression. For primary progressive MS, where symptoms steadily worsen over time, Ocrevus is the first and only treatment shown to slow the progression of physical disability.
While Ocrevus does not cure MS, it helps reduce inflammation, slow disability progression, and minimize new disease activity — supporting improved stability and quality of life. Patients can begin to see measurable effects from Ocrevus in as little as 12 weeks, with benefits continuing to increase over many months to a few years. Clinical trials have demonstrated sustained benefits over extended treatment periods, helping patients maintain function and reduce disease activity long-term.
Like all medications, Ocrevus can cause side effects. Common Ocrevus infusion side effects include:
Less common but serious side effects require immediate medical attention:
Rare but serious complications can include blood clots, heart failure, and stroke. Your healthcare team at our infusion center will monitor you closely during and after each Ocrevus IV infusion to ensure your safety.
The Ocrevus infusion cost depends on individual insurance coverage and benefits. At MS & Neuromuscular Center of Excellence, our team works to make treatment as seamless and affordable as possible for every patient.
We collaborate with most major commercial insurance providers throughout the region — including Aetna, BayCare, Advent Health, Cigna, AvMed, Assurant, and others. Our team works closely with your insurance company to maximize your coverage for Ocrevus treatment.
Our infusion staff provides comprehensive support to make treatment more accessible:
Our infusion center is staffed by board-certified neurologists and BSN-prepared Registered Nurses with extensive experience in neurological infusion care. Patients can expect expert oversight and compassionate, individualized support throughout treatment.
Our medical team brings specialized expertise in multiple sclerosis and complex neurological conditions. With advanced training and years of experience managing MS patients on anti-CD20 therapies, our team of health providers understand the unique considerations for both relapsing and progressive MS treatment.
Our clinical expertise extends beyond MS to include comprehensive care for myasthenia gravis, neuropathy, and other neurological disorders. We have advanced diagnostic capabilities, including electromyography, to provide complete neurological care in one convenient location.
We handle prior authorizations, verify benefits, and assist patients with copay and foundation support programs to reduce financial strain.
Studies, including one from Cigna, show that patients treated in physician-owned infusion centers — such as MS & Neuromuscular Center of Excellence’s Infusion Center — often pay less overall and out of pocket compared to hospital outpatient centers.
With over 35 years of service to the community, MS & Neuromuscular Center of Excellence’s has built a reputation for excellence in the treatment of MS and other neurological disorders. Our decades of experience mean we've treated thousands of patients with both relapsing and progressive MS, giving us deep insight into the challenges you face and the most effective treatment approaches.
Our established track record with Ocrevus infusion for multiple sclerosis and other anti-CD20 therapies means you benefit from a team that understands not just the science behind the treatment, but the real-world impact on patients' lives. Our team's experience, care, and dedication continue to make a meaningful difference for patients every day.
Referral Form:
Ocrevus®What It Treats:
Multiple Sclerosis
Primary Progressive Multiple Sclerosis
FDA Approval:
Ocrevus® (ocrelizumab): Approved on March 28, 2017
Manufacturer:
Genentech (a subsidiary of Roche)
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
Im so happy I found him he is caring and listens and will give you the best treatment.
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
I am a new patient and so far everything has been great.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I am a new patient and so far everything has been great.
Im so happy I found him he is caring and listens and will give you the best treatment.
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I am a new patient and so far everything has been great.
Im so happy I found him he is caring and listens and will give you the best treatment.
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I am a new patient and so far everything has been great.
Im so happy I found him he is caring and listens and will give you the best treatment.
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
