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Dr. Mark Cascione is a board-certified neurologist who has dedicated his career to caring for people with Multiple Sclerosis (MS) and other neurological conditions. Originally from Jackson, New Jersey, he began his medical journey with a strong foundation in science and research, including early work at Massachusetts General Hospital. In 1996, Dr. Cascione founded Tampa Neurology Associates, and later established the South Tampa MS Center to provide focused, compassionate care for individuals living with MS. He is known for taking the time to listen to his patients, helping them understand their condition, and working closely with them to create personalized treatment plans. In addition to his clinical work, Dr. Cascione has been deeply involved in advancing MS care through research. He has participated in over 300 clinical trials as a principal investigator or sub-investigator, giving his patients access to cutting-edge therapies and contributing to progress in MS treatment.
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Duke University Medical Center, Clinical Neurophysiology (1995–1996)
American Board of Psychiatry and Neurology — Neurology
Tampa Top Docs 2017, 2018, 2019, 2020 (Tampa Magazine)
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I have been to a few neurologists in the area and this is the best. I've seen both Dr. Schneider and ARNP Dawn Rush-Wilde. They never make me feel rushed and always listen to my concerns. The office staff is also helpful and nice. I know that several staff members are bilingual, but speak English very clearly. If you're looking for a neurologist, I highly recommend this office.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
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MS & Neuromuscular Center of Clearwater
3190 N McMullen Booth Road, Suite 200, Clearwater, FL 33761
MS & Neuromuscular Center of Tampa
Lutz, FL
September 9, 2026
Brain health is a lifelong journey shaped by lifestyle, environment, genetics, and quality care. Join us for a virtual 1-hour webinar featuring Dr. Augusto Miravalle, Dr. Mark Cascione, and Kara Menning, FNP-BC, MSN, MSCN, as they explore how the brain adapts over time and share practical, evidence-based strategies to help support cognitive function and long-term brain health.
August 11, 2026
Dr. Dinesh Sivakolundu of MS & Neuromuscular Center of Excellence in Clearwater, a neuroimmunologist who specializes in MS and complex autoimmune disorders of the nervous system, joined the NR Times podcast to talk about the parts of MS you can't see — cognition, fatigue, and mood. He explains why these symptoms get missed so often, what his research is uncovering about how MS changes the way the brain delivers and uses energy, and why a stable MRI doesn't always mean a patient is doing well.
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July 8, 2026
For many people living with MS, fatigue can affect everything from work to everyday activities. Join us for a virtual 1-hour webinar featuring MS experts Dr. Augusto Miravalle and Christina Weber, DNP, as they discuss the latest understanding of fatigue and fatiguability, the role of exercise in symptom management, and practical strategies to help you stay active and navigate daily life with greater confidence.
May 13, 2026
Join us for a virtual 1-hour webinar with MS experts as we discuss the latest advances in multiple sclerosis care and what they mean for patients today, along with practical ways to manage everyday challenges during the warmer months, including heat sensitivity, MS-related fatigue, and tips to stay active and conserve energy this summer.
March 25, 2026
Exercise is not just beneficial on a behavioral level, it directly impacts the neural signals that support memory, according to Dr. Dinesh Sivakolundu, of MS & Neuromuscular Center of Excellence in Clearwater, FL.
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