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Tysabri® (natalizumab) is a monoclonal antibody therapy used to treat relapsing forms of multiple sclerosis (RMS) in adults. Unlike therapies that deplete specific immune cells, Tysabri works by blocking the movement of immune cells into the brain and spinal cord, where they can cause inflammation and nerve damage.
What makes Tysabri unique is its mechanism of action—it prevents immune cells from entering the central nervous system by blocking the alpha-4 integrin protein, keeping harmful immune cells in the bloodstream instead. This targeted approach makes Tysabri a powerful high-efficacy treatment option for individuals with MS, helping to reduce relapses, slow disease progression, and limit new lesion formation in the brain.
Tysabri infusion is administered at our specialized infusion center. The typical treatment schedule includes:
After 12 infusions with no hypersensitivity reactions, your healthcare provider may adjust the observation period based on clinical judgment.
In multiple sclerosis (MS), the immune system attacks the myelin sheath — the protective layer that insulates and protects nerve fibers in the brain and spinal cord. This damaging immune activity occurs when harmful immune cells pass through the blood-brain barrier—a protective membrane that normally shields the central nervous system from potentially dangerous substances in the bloodstream.
Tysabri works through a unique mechanism that differs from other MS therapies:
This targeted approach makes Tysabri particularly effective compared to other MS treatments. While anti-CD20 therapies work by depleting B-cells throughout the body, Tysabri specifically prevents immune cells from entering the central nervous system while leaving the rest of the immune system relatively intact. This difference in mechanism leads to distinct side effect profiles and management considerations.
While not a cure, Tysabri helps stabilize MS activity, reduce flare-ups, and preserve nerve health over time. Tysabri starts working after the first dose, with many patients noticing beneficial effects within 12 weeks of starting Tysabri infusion treatment.
As a disease-modifying therapy, Tysabri is primarily intended to prevent new lesions and slow disease progression rather than immediately alleviate existing symptoms. Some patients may experience an adjustment period with initial side effects that typically subside within four months of continued treatment.
Because Tysabri requires careful Tysabri infusion monitoring due to potential serious side effects, it's only available through the TOUCH Prescribing Program, a restricted distribution program that ensures proper patient monitoring and safety protocols.
Common Tysabri infusion side effects include:
Serious Tysabri infusion side effects require immediate medical attention:
Your healthcare team provides comprehensive Tysabri infusion monitoring throughout your treatment, including observation during and after each infusion, regular MRI scans, and ongoing assessment for any neurological changes.
Tysabri infusion cost varies depending on your insurance provider and coverage. Our team at MS & Neuromuscular Center of Excellence works closely with patients to ensure affordable, accessible care.
We partner with most major insurance carriers throughout the region, including Aetna, BayCare, Advent Health, Cigna, AvMed, Assurant, and others.
Our staff provides comprehensive support to make treatment more accessible:
Our infusion center is led by board-certified neurologists and staffed by BSN-prepared Registered Nurses who specialize in infusion therapy for neurological disorders. Our team is fully trained in the TOUCH Program requirements and provides expert Tysabri infusion monitoring throughout your treatment.
Our comprehensive monitoring protocol includes:
Our clinical expertise extends beyond MS to include comprehensive care for myasthenia gravis, neuropathy, and other neurological conditions.
We manage prior authorizations, verify benefits, and help patients find copay and financial support programs to make Tysabri IV infusion more affordable.
A recent Cigna report shows that many patients treated at physician-owned infusion sites like MS & Neuromuscular Center of Excellence's Infusion Center experience lower out-of-pocket expenses than those treated in hospital settings.
Proudly serving patients across the region with expert, compassionate neurological care for more than 35 years. Our decades of experience with high-efficacy MS therapies means we understand both the remarkable benefits and the important safety considerations of Tysabri infusion treatment.
Referral Form:
Tysabri®What It Treats:
Crohn’s Disease
Multiple Sclerosis
Primary Progressive Multiple Sclerosis
FDA Approval:
Multiple Sclerosis (MS): Approved on November 23, 2004
Crohn’s Disease: Approved on January 14, 2008
Manufacturer:
Biogen
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
