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Ultomiris® (ravulizumab-cwvz) is a long-acting complement inhibitor used to treat several serious autoimmune and blood disorders in adults and children. At MS & Neuromuscular Center of Excellence, we specialize in using Ultomiris infusion therapy for neurological conditions including generalized myasthenia gravis (gMG) in adults who are anti-acetylcholine receptor (AChR) antibody-positive, and neuromyelitis optica spectrum disorder (NMOSD) in adults who are anti-aquaporin-4 (AQP4) antibody-positive.
What makes Ultomiris unique is its long-acting formulation, which allows for significantly fewer infusions compared to previous complement inhibitors. Patients typically receive treatment every 8 weeks rather than every 2 weeks, providing greater convenience while maintaining effective disease control.
Ultomiris infusion is administered at our specialized infusion center. The treatment schedule includes:
Weight-Based Dosing Schedule (Adults 40 kg or more):
Infusion Duration:
Important Safety Requirement: Because Ultomiris affects the immune system's ability to fight certain infections, vaccination against meningococcal bacteria is required before starting treatment. Additional vaccinations against Streptococcus pneumoniae and Haemophilus influenzae are also recommended.
In autoimmune neurological conditions like myasthenia gravis and neuromyelitis optica spectrum disorder, the body's immune system mistakenly attacks healthy tissue. A key part of this attack involves the complement system, a series of proteins that normally help fight infections but can cause damage when overactivated.
Specifically, the complement system can attack:
Ultomiris works through a specific mechanism:
Ultomiris provides immediate, complete, and sustained C5 complement inhibition after the first dose, with initial results often appearing quickly. For generalized myasthenia gravis, many patients notice improvements in daily activities (e.g., talking, chewing, swallowing, and standing up) within 1 week of starting treatment. While Ultomiris does not cure these conditions, it helps control disease activity, reduce symptoms, and improve quality of life.
Common Ultomiris infusion side effects include:
Serious Ultomiris infusion side effects require immediate medical attention:
Your healthcare team provides comprehensive monitoring throughout your treatment, including observation during and after each infusion and ongoing assessment for any signs of infection.
The Ultomiris infusion cost depends on insurance coverage and provider. At MS & Neuromuscular Center of Excellence, we're dedicated to improving access and affordability for all our patients.
We work with most major insurance plans throughout the region, including Aetna, BayCare, Advent Health, Cigna, AvMed, Assurant, and others. Our team works closely with your insurance company to ensure you receive maximum coverage for your Ultomiris treatment.
Our infusion staff provides comprehensive support to make treatment more accessible:
Our infusion center is led by board-certified neurologists and supported by a team of BSN-prepared Registered Nurses who specialize in neurological infusion care.
Our comprehensive approach includes:
Our clinical expertise extends to comprehensive care for multiple sclerosis, neuropathy, and other neurological disorders as well.
We help patients handle insurance paperwork and access copay and foundation assistance to make treatment more affordable.
A Cigna report recently found that infusions at physician-owned centers like MS & Neuromuscular Center of Excellence's Infusion Center often result in lower overall costs than at hospital outpatient centers.
With 35+ years of expertise in neurological care, MS & Neuromuscular Center of Excellence proudly serves patients across the state. Our established reputation and proven track record with immunotherapy and infusion treatments give patients confidence they're receiving care from a team with extensive experience in managing complement inhibitor therapy.
Referral Form:
Ultomiris®What It Treats:
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Atypical Hemolytic Uremic Syndrome (AHUS)
Generalised Myasthenia Gravis
Neuromyelitis Optica Spectrum Disorder (NMOSD)
FDA Approval:
Paroxysmal Nocturnal Hemoglobinuria (PNH): Approved on December 21, 2018
Atypical Hemolytic Uremic Syndrome (AHUS): Approved on October 18, 2019
Generalised Myasthenia Gravis: Approved on April 28, 2022
Neuromyelitis Optica Spectrum Disorder (NMOSD): Approved on March 25, 2024
Manufacturer:
Alexion Pharmaceuticals, Inc.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
Dr. Rivera Vega was extremely caring, she listened to me, she read my records and discussed the plan with me. Very thorough exam and excellent care!
I was able to see Dr. Nelitza Rivera-Vega and the visit was pristine! The front desk staff and nurse were so sweet and helpful. Multiple Sclerosis can be such a scary illness but Dr. Rivera-Vega was so thorough during the entire exam. She gathered my entire history with time and patience. Would recommend this office to anyone!
Dr. Rivera Vega is a wonderful, compassionate and kind doctor. She takes her time with each patient. She is very knowledgeable and wants to make sure her patients understand everything that’s going on. I highly recommend her!
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dr Lee is extremely thorough and caring! She always answers all my questions and takes adequate time addressing all of my medical concerns. Great Care!!!
Dr Lee is an excellent doctor that has provided me with expert care. I suffer from acute neuropathy and she was able to provide treatment and found part of my pain was actually coming from my lower back. After having my back treated the pain has been significantly reduced. I'm so glad and fortunate to have found such a great neurologist
Dr Lee is kind, thorough in her exam, and explains diseases and treatments in an easy way to understand. She is a very likable and knowledgeable doctor. The clinic is well ran and the front desk staff were genuinely nice not only to me but to the other patients as well. I am so happy with this clinic and doctor after my original doctor retired
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Dr Rivera-Vega did a great job spent adequate time, and was very knowledgeable in all aspects of my neurological health. I am very happy to have her as my neurologist!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dr. Lee is very personable, professional, and knowledgeable. She is not rushed and spends all the necessary time with you during the visit, answering all questions, I highly recommend a Dr. Lee.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
