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Vyepti® (eptinezumab-jjmr) is an IV infusion treatment for adults designed to prevent migraine attacks before they start. It works by blocking calcitonin gene-related peptide (CGRP), a protein that contributes to migraine pain and inflammation in the brain. By inhibiting CGRP, Vyepti® helps reduce the frequency, intensity, and duration of migraine episodes.
Vyepti is FDA-approved for the preventive treatment of migraine in adults with both episodic migraine (fewer than 15 headache days per month) and chronic migraine (15 or more headache days per month). It's particularly beneficial for patients who have not found adequate relief with or cannot tolerate oral preventive medications.
What makes Vyepti unique among migraine preventive treatments is its delivery method and dosing schedule. Unlike oral CGRP medications that require daily pills or injectable CGRP inhibitors that require monthly self-injections, Vyepti is administered as an IV infusion just once every 3 months at a healthcare facility. This quarterly schedule offers superior convenience and ensures consistent medication delivery without the burden of daily or monthly dosing.
Vyepti infusion is administered at our specialized infusion center. The treatment details include:
Vyepti Infusion Frequency and Schedule:
Dosing Options:
Vyepti IV Infusion Duration:
Migraine is a complex neurological condition involving abnormal brain activity, inflammation, and changes in blood flow. Research has identified calcitonin gene-related peptide (CGRP) as a key player in triggering and sustaining migraine attacks. CGRP levels spike during migraines, causing:
Vyepti works through a targeted mechanism:
What sets Vyepti apart from other CGRP inhibitors is its intravenous delivery and rapid action. Because it's administered directly into the bloodstream, Vyepti achieves immediate therapeutic levels without relying on oral absorption or subcutaneous injection. This allows for faster onset of action compared to other CGRP treatments.
While Vyepti doesn't cure migraines, it's a preventive therapy that can dramatically reduce the occurrence and severity of migraine attacks over time, helping patients regain control of their lives and reduce their reliance on acute migraine medications.
Common Vyepti infusion side effects are generally mild and may lessen as your body adjusts:
Serious Vyepti infusion side effects require immediate medical attention. Vyepti can cause hypersensitivity reactions, including life-threatening allergic responses. Seek emergency help if you experience:
Your healthcare team will monitor you during and after each infusion for any signs of allergic or hypersensitivity reactions to ensure your safety.
The Vyepti infusion cost depends on insurance coverage and provider. At MS & Neuromuscular Center of Excellence, we're dedicated to improving access and affordability for all our patients seeking effective migraine prevention.
We work with most major insurance plans throughout Florida, including Aetna, BayCare, Advent Health, Cigna, AvMed, Assurant, and others.
Our infusion staff provides comprehensive support to make treatment more accessible:
Our infusion center is led by board-certified neurologists and supported by a team of BSN-prepared Registered Nurses who specialize in neurological infusion care. Our team has extensive experience treating patients with both episodic and chronic migraine.
Our approach to migraine treatment includes:
Beyond migraine care, our comprehensive neurological expertise extends to multiple sclerosis, myasthenia gravis, and other conditions.
We help patients handle insurance paperwork and access copay and foundation assistance to make treatment more affordable.
A Cigna report recently found that infusions at physician-owned centers like MS & Neuromuscular Center of Excellence's Infusion Center often result in lower overall costs than at hospital outpatient centers, making your quarterly Vyepti treatments more economical.
Proudly serving patients across the region with expert, compassionate neurological care for more than 35 years. Our decades of experience treating complex neurological conditions means we understand how debilitating chronic migraines can be and how transformative effective preventive treatment can be for our patients.
Our established reputation and commitment to staying current with the latest migraine treatments, including innovative therapies like Vyepti, give patients confidence they're receiving cutting-edge care from an experienced team.
Referral Form:
Vyepti®What It Treats:
Migraine
FDA Approval:
Migraine: Approved on February 22, 2020
Manufacturer:
Lundbeck Inc.
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I am a new patient and so far everything has been great.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Im so happy I found him he is caring and listens and will give you the best treatment.
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I am a new patient and so far everything has been great.
Im so happy I found him he is caring and listens and will give you the best treatment.
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I am a new patient and so far everything has been great.
Im so happy I found him he is caring and listens and will give you the best treatment.
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
I had a great experience with Dr Cascione. He is the go to for MS. Extremely knowledgeable. Answered all my questions. He took lots of time with me. I checked in, and they took me right away.The staff is very nice. Five stars from me.
I felt very comfortable with Dr Cascione. He is very knowledgeable I found I trusted him immediately which is rare for me I have been to many Md’s for my MS he knows what MS is all about.
Short wait, employees are friendly and helpful. Dr Cascione is very knowledgeable, patient and listens. He takes notes to remember everything you tell him and is very compassionate. He suggests new meds that may benefit you. Everyone in the office makes you feel welcome and cared for.
Dr Cascione is the best! I have been seeing him for a long time. He listens to what I have to say. He spends a lot of time in the room and when you are done you know he has gone over everything. He is compassionate, caring and just an over all good Dr. I highly recommend anyone who has Multiple Sclerosis to use him as your neurologist.
My daughter has MS, we had an appointment with Dr. Cascione and I have nothing but praises to say about this doctor. He spent so long in the room talking to me and my daughter about MS, treatment, and lifestyle choices to aid my daughter in understanding her MS. Dr. Cascione was so easy to talk to and so kind throughout the entire appointment.
I am a new patient and so far everything has been great.
Im so happy I found him he is caring and listens and will give you the best treatment.
Dr. Sivakolundu is an excellent doctor. He’s knowledgeable and competent. He and his staff are very friendly. I’d absolutely recommend this place.
Dr Sivakolundu was very thorough, caring, and listened to all my questions. He took his time and I felt I had his undivided attention through the entire appointment.
Dr. Sivakolundu is incredibly knowledgeable and genuinely kind. He takes his time, listens carefully, and never makes you feel rushed or dismissed. I truly appreciated his patience and professionalism. Highly recommend.
I saw Dr Sivakolundu for the first time yesterday and he did more for me in one appointment then my previous neuro did in 6 months. I feel blessed to have found him and totally trust my care in his hands.
Dr. Schneider and his team….WOW!!! I am super impressed on my first visit. Very knowledgeable, professional and kind. Dr. Schneider was thorough in addressing all my concerns and he sets the bar high for all other doctors! Their office is beautiful and comforting….again setting the bar high.
This was my first visit for migraines and Shreya Patel NP made me feel completely at ease. She took the time to answer every question and explained everything before we began. I highly recommend her and the entire staff.
Sherya Patel has been the kindest, patient, most helpful & professional ARPN I’ve ever encountered. She takes the time to answer all our questions. My husband and I have seen her for years and couldn’t be happier.
I am always pleased with Shreya! She is friendly and professional, answers all of my questions and my treatment is quick and virtually pain free.
Ms. Patel is extremely knowledgeable and understanding. I appreciate the efficiency of our visits as well as the thoroughness. My treatment plan approach is outstanding. The meds attack my dual diagnosis of different headaches and is very effective. She always confirms to make sure the efficacy of the treatment plan each visit. I feel extremely comfortable being in her care
She was great. Couldn't ask for anybody better. Hopefully, hopefully, he will keep up that good work and that communication. She listened well. I want to say that she needs to not change anything about herself
Dawn is attentive and compassionate regarding my ailments. Very informative, discusses all options of treatment. Most importantly I feel “Heard” and I feel safe with her
I had a wonderful experience with Dawn Rushe-Wilde, ARNP. She was very thorough in her exam and took the time to answer all my questions. I would highly recommend her!
Dawn came in the exam room fully prepared, including looking at the forms I had just brought in from a recent medical visit elsewhere. She is familiar with my history and asks for any updates from me. She explains things thoroughly, taking time to answer any questions and to make recommendations. Thank you, Dawn, for your excellent care
Dr. Jean-Raphael Schneider and his team are amazing. He truly listened to my migraine problems and have developed a plan to help me. Dr. Schneider's expertise in his field is evident, and it's clear that he is highly educated. I feel confident in his ability to help me overcome my migraines.
He is a 5 star migraine management specialist and I am grateful to have found him when I so desperately needed migraine relief. I wish he and all of his staff well
I am so grateful for Dr. Schneider and his staff. My 15 year old daughter started getting debilitating migraines about 2 years ago. His staff was incredible and was able to get her in to see him on short notice! He was thorough (poured over all her medical records), compassionate (made connections with my daughter through athletics), and really listened. I left his neurologist's office and felt a sense of hope. Thank you, Dr. Schneider and staff!!
I never leave reviews but Dr. Schneider is extremely helpful and reassuring. He personally called and went over my results multiple times and answered any question I had. He has extremely well bedside manner and is very knowledgeable. His staff is extremely nice as well!
Wonderful, caring neurology group with excellent listening skills and proactive modalities. "Dr" Dawn (APRN) is fabulous with botox. Love them.
Dawn Rush-Wild is very thorough doctor and a thoughtful listener. She provides options and doesn't push you into any of them. She has your best interests at heart.
